Protein profile

KP13_04746

DNA gyrase inhibitory protein

Genome: KpKP13

Gene: gyrI AHE43709.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQL6
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Amino acids 157
Annotations 2
Features 11
PDB binders 0
Druggability 0.934

Overview

Basic information about this protein and its source genome.

Accession
KP13_04746
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
gyrI AHE43709.1
Status
annotated
Amino acids
157
Structure source
AlphaFold + ColabFold
GO
GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
65.359
DEG E-value
2.4100000000000003e-73
Localization
Cytoplasmic
ColabFold pLDDT
97.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.934
Structure A0A0H3GQL6
Pocket Pocket 3
P2Rank 0.932
Structure A0A0H3GQL6
Pocket Pocket 1
ColabFold model
FPocket 0.347 · Pocket 6
P2Rank 0.939 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 155 Hamap MF_01896 DNA gyrase inhibitor [sbmC].
1 155 InterPro IPR024911 DNA gyrase inhibitor GyrI
1 154 PANTHER PTHR40055 TRANSCRIPTIONAL REGULATOR YGIV-RELATED
1 153 SMART SM00871 AraC_E_bind_2
1 153 InterPro IPR010499 Bacterial transcription activator, effector binding
1 154 Gene3D G3DSA:3.20.80.10 Regulatory factor, effector binding domain
1 154 InterPro IPR011256 Regulatory factor, effector binding domain superfamily
4 152 Pfam PF14526 Integron-associated effector binding protein
4 152 InterPro IPR029441 Integron-associated effector binding protein
1 153 SUPERFAMILY SSF55136 Probable bacterial effector-binding domain
1 153 InterPro IPR011256 Regulatory factor, effector binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQL6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04746
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.934

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.88 0.923