Protein profile

KP13_31887

Lipoate-protein ligase A

Genome: KpKP13

Gene: AHE43718.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVQ9
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Amino acids 246
Annotations 1
Features 8
PDB binders 0
Druggability 0.933

Overview

Basic information about this protein and its source genome.

Accession
KP13_31887
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43718.1
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
GO
GO:0036211 The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.933
Structure A0A0H3GVQ9
Pocket Pocket 1
P2Rank 0.608
Structure A0A0H3GVQ9
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 1
P2Rank 0.779 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0036211 The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
24 246 Gene3D G3DSA:3.30.930.10 Bira Bifunctional Protein; Domain 2
24 246 InterPro IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
67 194 PANTHER PTHR43679 OCTANOYLTRANSFERASE LIPM-RELATED
28 238 SUPERFAMILY SSF55681 Class II aaRS and biotin synthetases
28 238 InterPro IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
34 242 CDD cd16443 LplA
39 242 ProSiteProfiles PS51733 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) catalytic domain profile.
39 242 InterPro IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVQ9
AlphaFold — — full sequence — Viewing
ColabFold KP13_31887
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.933

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.5 0.394
2 1.05 0.006