Protein profile

KP13_04774

putative regulatory protein TetR

Genome: KpKP13

Gene: AHE43737.1 Structure source: AlphaFold + ColabFold UniProt A0A080T0H7
Export view
Amino acids 234
Annotations 1
Features 13
PDB binders 0
Druggability 0.855

Overview

Basic information about this protein and its source genome.

Accession
KP13_04774
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43737.1
Status
annotated
Amino acids
234
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.855
Structure A0A080T0H7
Pocket Pocket 1
P2Rank 0.72
Structure A0A080T0H7
Pocket Pocket 1
ColabFold model
FPocket 0.915 · Pocket 1
P2Rank 0.738 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 15 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
31 72 Pfam PF00440 Bacterial regulatory proteins, tetR family
31 72 InterPro IPR001647 DNA-binding HTH domain, TetR-type
25 217 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
17 94 SUPERFAMILY SSF46689 Homeodomain-like
17 94 InterPro IPR009057 Homeobox-like domain superfamily
24 203 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
215 234 MobiDBLite mobidb-lite consensus disorder prediction
98 211 Pfam PF16925 Tetracyclin repressor-like, C-terminal domain
98 211 InterPro IPR011075 Tetracyclin repressor-like, C-terminal domain
98 208 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
98 208 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
24 84 ProSiteProfiles PS50977 TetR-type HTH domain profile.
24 84 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A080T0H7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04774
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.855

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.81 0.663