Protein profile

KP13_04790

NAD(P)-binding domain-containing protein

Genome: KpKP13

Gene: AHE43753.1 Structure source: AlphaFold + ColabFold UniProt A0A2P0B9S2
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Amino acids 589
Annotations 4
Features 10
PDB binders 0
Druggability 0.147

Overview

Basic information about this protein and its source genome.

Accession
KP13_04790
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43753.1
Status
annotated
Amino acids
589
Structure source
AlphaFold + ColabFold
GO
GO:0008641 Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0061503 Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. GO:0061504 The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.147
Structure A0A2P0B9S2
Pocket Pocket 3
P2Rank 0.779
Structure A0A2P0B9S2
Pocket Pocket 1
ColabFold model
FPocket 0.248 · Pocket 2
P2Rank 0.732 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008641 Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
  • GO:0061503 Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.
  • GO:0061504 The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
349 487 CDD cd01483 E1_enzyme_family
331 586 Gene3D G3DSA:3.40.50.720 -
208 534 PANTHER PTHR43267 TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE
208 534 InterPro IPR045886 ThiF/MoeB/HesA family
344 588 SUPERFAMILY SSF69572 Activating enzymes of the ubiquitin-like proteins
344 588 InterPro IPR035985 Ubiquitin-activating enzyme
340 527 Pfam PF00899 ThiF family
340 527 InterPro IPR000594 THIF-type NAD/FAD binding fold
13 152 Pfam PF14461 Prokaryotic E2 family B
13 152 InterPro IPR032701 Prokaryotic E2 family B domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2P0B9S2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04790
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.78 0.578
2 3.21 0.111
3 1.29 0.013
4 1.25 0.012
5 1.16 0.009