Protein profile

KP13_04805

Type IV secretion system protein virB9

Genome: KpKP13

Gene: AHE43770.1 virB9 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVN2
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Amino acids 302
Annotations 0
Features 17
PDB binders 0
Druggability 0.432

Overview

Basic information about this protein and its source genome.

Accession
KP13_04805
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43770.1 virB9
Status
annotated
Amino acids
302
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.432
Structure A0A0H3GVN2
Pocket Pocket 3
P2Rank
Structure A0A0H3GVN2
Pocket No pockets
ColabFold model
FPocket 0.408 · Pocket 4
P2Rank 0.005 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
5 278 NCBIfam TIGR02781 P-type conjugative transfer protein VirB9
5 278 InterPro IPR014148 P-type conjugative transfer protein VirB9
187 277 CDD cd06911 VirB9_CagX_TrbG
187 277 InterPro IPR033645 VirB9/CagX/TrbG, C-terminal
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
168 301 Gene3D G3DSA:2.60.40.2500 -
168 301 InterPro IPR038161 VirB9/CagX/TrbG, C-terminal domain superfamily
150 168 MobiDBLite mobidb-lite consensus disorder prediction
31 275 Pfam PF03524 Conjugal transfer protein
31 275 InterPro IPR010258 Conjugal transfer, TrbG/VirB9/CagX
21 302 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
150 170 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVN2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04805
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.432
5 0.284