Protein profile

KP13_04810

type IV secretion system VirB5 component

Genome: KpKP13

Gene: AHE43775.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV28
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Amino acids 234
Annotations 0
Features 13
PDB binders 0
Druggability 0.4

Overview

Basic information about this protein and its source genome.

Accession
KP13_04810
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43775.1
Status
annotated
Amino acids
234
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
77.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.4
Structure A0A0H3GV28
Pocket Pocket 2
P2Rank 0.038
Structure A0A0H3GV28
Pocket Pocket 1
ColabFold model
FPocket 0.347 · Pocket 21
P2Rank 0.042 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
22 234 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 215 Pfam PF07996 Type IV secretion system proteins
22 215 InterPro IPR014158 Type IV secretion system, VirB5
7 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
41 61 Coils Coil Coil
22 218 Gene3D G3DSA:1.20.58.430 -
22 218 InterPro IPR023220 Type IV secretion system, VirB5-domain
22 217 SUPERFAMILY SSF101082 Typo IV secretion system protein TraC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV28
AlphaFold — — full sequence — Viewing
ColabFold KP13_04810
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.4
1 0.235