Protein profile

KP13_04811

Type IV secretion system protein virB4

Genome: KpKP13

Gene: AHE43776.1 virB4 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVM7
Export view
Amino acids 912
Annotations 2
Features 19
PDB binders 0
Druggability 0.728

Overview

Basic information about this protein and its source genome.

Accession
KP13_04811
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43776.1 virB4
Status
annotated
Amino acids
912
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.728
Structure A0A0H3GVM7
Pocket Pocket 7
P2Rank 0.378
Structure A0A0H3GVM7
Pocket Pocket 1
ColabFold model
FPocket 0.397 · Pocket 12
P2Rank 0.415 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
12 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
661 823 PANTHER PTHR30121 UNCHARACTERIZED PROTEIN YJGR-RELATED
477 827 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
477 827 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 79 Pfam PF05101 Type IV secretory pathway, VirB3-like protein
3 79 InterPro IPR007792 Type IV secretion system, VirB3 / TrbD / AvhB
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
525 818 Gene3D G3DSA:3.40.50.300 -
525 818 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
735 812 CDD cd01127 TrwB_TraG_TraD_VirD4
535 813 Pfam PF19044 TraG P-loop domain
535 813 InterPro IPR043964 TraG, P-loop domain
45 912 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
369 389 Coils Coil Coil
226 246 Coils Coil Coil
581 713 Gene3D G3DSA:1.10.8.730 -
269 470 Pfam PF03135 CagE, TrbE, VirB family, component of type IV transporter system
269 470 InterPro IPR018145 CagE, TrbE, VirB component of type IV transporter system, central domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVM7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04811
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.728
4 0.368
9 0.343

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.71 0.206
2 4.3 0.178
3 4.28 0.177
4 2.21 0.053
5 2.17 0.051