Protein profile

KP13_04833

Protein mtfA

Genome: KpKP13

Gene: mtfA AHE43800.1 Structure source: Experimental + ColabFold UniProt A6TB83
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Amino acids 266
Annotations 1
Features 15
PDB binders 0
Druggability 0.361

Overview

Basic information about this protein and its source genome.

Accession
KP13_04833
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mtfA AHE43800.1
Status
annotated
Amino acids
266
Structure source
Experimental + ColabFold
GO
GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
76.981
DEG E-value
2.36e-155
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.51

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.361
Structure 3DL1
Pocket Pocket 5
P2Rank 0.519
Structure 3KHI
Pocket Pocket 1
ColabFold model
FPocket 0.509 · Pocket 19
P2Rank 0.711 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
15 255 PANTHER PTHR30164 MTFA PEPTIDASE
15 255 InterPro IPR010384 MtfA family
36 246 SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain
36 243 CDD cd20169 Peptidase_M90_mtfA
36 243 InterPro IPR010384 MtfA family
141 263 FunFam G3DSA:3.40.390.10:FF:000012 Protein MtfA
2 266 Hamap MF_01593 Protein MtfA [mtfA].
2 266 InterPro IPR010384 MtfA family
17 140 FunFam G3DSA:1.10.472.150:FF:000001 Protein MtfA
16 140 Gene3D G3DSA:1.10.472.150 -
16 140 InterPro IPR042252 MtfA, N-terminal
20 244 Pfam PF06167 Glucose-regulated metallo-peptidase M90
20 244 InterPro IPR010384 MtfA family
141 266 Gene3D G3DSA:3.40.390.10 Collagenase (Catalytic Domain)
141 266 InterPro IPR024079 Metallopeptidase, catalytic domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3DL1
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
PDB 3KHI
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Loaded
ColabFold KP13_04833
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.361