Protein profile

KP13_01661

Inner membrane amino-acid ABC transporter permease protein

Genome: KpKP13

Gene: AHE43817.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQD0
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Amino acids 222
Annotations 6
Features 25
PDB binders 0
Druggability 0.866

Overview

Basic information about this protein and its source genome.

Accession
KP13_01661
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43817.1
Status
annotated
Amino acids
222
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015184 Enables the transfer of L-cystine from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.243
DEG E-value
5.61e-153
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.866
Structure A0A0H3GQD0
Pocket Pocket 2
P2Rank 0.079
Structure A0A0H3GQD0
Pocket Pocket 1
ColabFold model
FPocket 0.798 · Pocket 3
P2Rank 0.111 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 149 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0015184 Enables the transfer of L-cystine from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
19 207 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
19 207 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
3 217 FunFam G3DSA:1.10.3720.10:FF:000009 Amino acid ABC transporter permease
186 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 54 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
33 214 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
33 214 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10 218 PANTHER PTHR30614 MEMBRANE COMPONENT OF AMINO ACID ABC TRANSPORTER
10 218 InterPro IPR043429 ABC transporter membrane protein permease protein ArtM/GltK/GlnP/TcyL/YhdX-like
185 207 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
79 185 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
54 76 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 109 NCBIfam TIGR01726 ABC transporter permease subunit, His/Glu/Gln/Arg/opine family, N-terminal region
12 109 InterPro IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain
20 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 222 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 219 Gene3D G3DSA:1.10.3720.10 -
3 219 InterPro IPR035906 MetI-like superfamily
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 200 SUPERFAMILY SSF161098 MetI-like
13 200 InterPro IPR035906 MetI-like superfamily
22 204 CDD cd06261 TM_PBP2
22 204 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
55 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQD0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01661
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.866
6 0.217
9 0.212

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.55 0.131
2 1.94 0.04
3 1.23 0.012