Protein profile

KP13_13083

Tyrosine-specific transport protein

Genome: KpKP13

Gene: ANJ86600.1 tyrP Structure source: AlphaFold + ColabFold UniProt A0A0H3GVK1
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Amino acids 403
Annotations 5
Features 64
PDB binders 0
Druggability 0.984

Overview

Basic information about this protein and its source genome.

Accession
KP13_13083
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86600.1 tyrP
Status
annotated
Amino acids
403
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333 The process in which an amino acid is transported across a membrane. GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
80.893
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.984
Structure A0A0H3GVK1
Pocket Pocket 12
P2Rank 0.868
Structure A0A0H3GVK1
Pocket Pocket 1
ColabFold model
FPocket 0.952 · Pocket 8
P2Rank 0.894 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 104 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0003333 The process in which an amino acid is transported across a membrane.
  • GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.
  • GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

Sequence Features

Domain/signature hits from InterPro and related databases.

64 records
Show feature table
Start End DB Term Name
30 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
357 376 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
170 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
316 334 PRINTS PR00166 Aromatic amino acid permease signature
316 334 InterPro IPR013059 Tryptophan/tyrosine transporter
148 168 PRINTS PR00166 Aromatic amino acid permease signature
148 168 InterPro IPR013059 Tryptophan/tyrosine transporter
37 56 PRINTS PR00166 Aromatic amino acid permease signature
37 56 InterPro IPR013059 Tryptophan/tyrosine transporter
182 204 PRINTS PR00166 Aromatic amino acid permease signature
182 204 InterPro IPR013059 Tryptophan/tyrosine transporter
221 240 PRINTS PR00166 Aromatic amino acid permease signature
221 240 InterPro IPR013059 Tryptophan/tyrosine transporter
337 356 PRINTS PR00166 Aromatic amino acid permease signature
337 356 InterPro IPR013059 Tryptophan/tyrosine transporter
10 33 PRINTS PR00166 Aromatic amino acid permease signature
10 33 InterPro IPR013059 Tryptophan/tyrosine transporter
282 301 PRINTS PR00166 Aromatic amino acid permease signature
282 301 InterPro IPR013059 Tryptophan/tyrosine transporter
82 102 PRINTS PR00166 Aromatic amino acid permease signature
82 102 InterPro IPR013059 Tryptophan/tyrosine transporter
121 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 403 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 384 NCBIfam TIGR00837 aromatic amino acid transporter
7 384 InterPro IPR013059 Tryptophan/tyrosine transporter
186 208 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
205 215 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
149 171 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
217 236 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 272 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 33 ProSitePatterns PS00594 Aromatic amino acids permeases signature.
17 33 InterPro IPR013061 Tryptophan/tryrosine permease, conserved site
18 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
181 204 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
59 77 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 400 FunFam G3DSA:1.20.1740.10:FF:000032 Tyrosine-specific transport system
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
2 390 Pfam PF03222 Tryptophan/tyrosine permease family
2 390 InterPro IPR018227 Amino acid/polyamine transporter 2
311 330 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
216 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
307 329 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
33 55 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 402 PANTHER PTHR46997 LOW AFFINITY TRYPTOPHAN PERMEASE-RELATED
2 402 InterPro IPR013059 Tryptophan/tyrosine transporter
78 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
377 399 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
273 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
273 295 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 310 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
331 335 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
336 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
377 399 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 402 Gene3D G3DSA:1.20.1740.10 Amino acid/polyamine transporter I
142 147 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
148 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 120 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVK1
AlphaFold — — full sequence — Viewing
ColabFold KP13_13083
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.984
26 0.279
3 0.224

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.93 0.632
2 11.52 0.614
3 6.03 0.297
4 3.49 0.127
5 3.25 0.113