Protein profile

KP13_01650

Ferritin-1

Genome: KpKP13

Gene: ftnA AHE43827.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H084
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Amino acids 165
Annotations 8
Features 13
PDB binders 6
Druggability 0.587

Overview

Basic information about this protein and its source genome.

Accession
KP13_01650
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ftnA AHE43827.1
Status
annotated
Amino acids
165
Structure source
AlphaFold + ColabFold
EC
1.16.3.2
GO
GO:0008199 Binding to a ferric iron ion, Fe(III). GO:0006879 A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008198 Binding to a ferrous iron ion, Fe(II). GO:0004322 Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.485
DEG E-value
1.86e-112
Localization
Cytoplasmic
ColabFold pLDDT
95.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.587
Structure A0A0H3H084
Pocket Pocket 3
P2Rank 0.024
Structure A0A0H3H084
Pocket Pocket 1
ColabFold model
FPocket 0.121 · Pocket 1
P2Rank 0.195 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 134 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0008199 Binding to a ferric iron ion, Fe(III).
  • GO:0006879 A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
  • GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008198 Binding to a ferrous iron ion, Fe(II).
  • GO:0004322 Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
  • GO:0042802 Binding to an identical protein or proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
5 158 CDD cd01055 Nonheme_Ferritin
5 158 InterPro IPR041719 Ferritin, prokaryotic-type
4 160 SUPERFAMILY SSF47240 Ferritin-like
4 160 InterPro IPR009078 Ferritin-like superfamily
1 165 FunFam G3DSA:1.20.1260.10:FF:000001 Non-heme ferritin
7 142 Pfam PF00210 Ferritin-like domain
7 142 InterPro IPR008331 Ferritin/DPS protein domain
1 145 ProSiteProfiles PS50905 Ferritin-like diiron domain profile.
1 145 InterPro IPR009040 Ferritin-like diiron domain
1 165 Gene3D G3DSA:1.20.1260.10 -
1 165 InterPro IPR012347 Ferritin-like
4 158 PANTHER PTHR11431 FERRITIN
4 158 InterPro IPR001519 Ferritin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H084
AlphaFold — — full sequence — Viewing
ColabFold KP13_01650
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.587
4 0.028
1 0.008
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.7 0.024

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FEO
4ZTT
P0A998 127.7 Da LogP -0.07 TPSA 9.2 ✓ Ro5 ✓ Clean O([Fe])[Fe]
LFA
1Z4A
Q9X0L2 282.6 Da LogP 8.05 TPSA 0.0 1 viol. ✓ Clean CCCCCCCCCCCCCCCCCCCC
O
4ZTT
P0A998 18.0 Da LogP -0.82 TPSA 31.5 ✓ Ro5 ✓ Clean O
OFO
4XGS
P0A998 144.7 Da LogP -0.63 TPSA 29.5 ✓ Ro5 ✓ Clean O[Fe]O[Fe]
OXY
4ZTT
P0A998 32.0 Da LogP 0.07 TPSA 34.1 ✓ Ro5 ✓ Clean O=O
PER
4ZTT
P0A998 32.0 Da LogP -2.38 TPSA 46.1 ✓ Ro5 ✓ Clean [O-][O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.