Protein profile

KP13_01606

Inner membrane protein

Genome: KpKP13

Gene: AHE43871.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRY8
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Amino acids 219
Annotations 0
Features 15
PDB binders 0
Druggability 0.989

Overview

Basic information about this protein and its source genome.

Accession
KP13_01606
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43871.1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
65.0
DEG E-value
1.54e-80
Localization
CytoplasmicMembrane
ColabFold pLDDT
68.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.989
Structure A0A0H3GRY8
Pocket Pocket 1
P2Rank 0.218
Structure A0A0H3GRY8
Pocket Pocket 1
ColabFold model
FPocket 0.655 · Pocket 18
P2Rank 0.238 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 72 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
28 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 27 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
93 211 SUPERFAMILY SSF158682 TerB-like
93 211 InterPro IPR029024 TerB-like
73 219 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
51 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 209 Pfam PF04391 Protein of unknown function (DUF533)
32 209 InterPro IPR007486 Inner membrane protein YebE
105 198 CDD cd07178 terB_like_YebE
105 198 InterPro IPR007486 Inner membrane protein YebE
45 50 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 72 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
80 218 Gene3D G3DSA:1.10.3680.10 -
80 218 InterPro IPR029024 TerB-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRY8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01606
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.989

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.13 0.167