Protein profile

KP13_01604

Exodeoxyribonuclease 10

Genome: KpKP13

Gene: exoX AHE43873.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ46
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Amino acids 219
Annotations 4
Features 12
PDB binders 0
Druggability 0.447

Overview

Basic information about this protein and its source genome.

Accession
KP13_01604
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
exoX AHE43873.1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0045004 Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.447
Structure A0A0H3GQ46
Pocket Pocket 3
P2Rank 0.787
Structure A0A0H3GQ46
Pocket Pocket 1
ColabFold model
FPocket 0.485 · Pocket 9
P2Rank 0.68 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003676 Binding to a nucleic acid.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
  • GO:0045004 Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
174 203 Pfam PF20600 Exodeoxyribonuclease X-like C-terminal
174 203 InterPro IPR046768 Exodeoxyribonuclease X-like, C-terminal
1 156 SMART SM00479 exoiiiendus
1 156 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
4 168 PANTHER PTHR30231 DNA POLYMERASE III SUBUNIT EPSILON
4 148 CDD cd06127 DEDDh
1 172 Gene3D G3DSA:3.30.420.10 -
1 172 InterPro IPR036397 Ribonuclease H superfamily
4 184 SUPERFAMILY SSF53098 Ribonuclease H-like
4 184 InterPro IPR012337 Ribonuclease H-like superfamily
4 147 Pfam PF00929 Exonuclease
4 147 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ46
AlphaFold — — full sequence — Viewing
ColabFold KP13_01604
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.447
1 0.289

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.19 0.677