Protein profile

KP13_01593

Inner membrane protein

Genome: KpKP13

Gene: AHE43882.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRX1
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Amino acids 427
Annotations 0
Features 34
PDB binders 0
Druggability 0.702

Overview

Basic information about this protein and its source genome.

Accession
KP13_01593
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43882.1
Status
annotated
Amino acids
427
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.702
Structure A0A0H3GRX1
Pocket Pocket 26
P2Rank 0.586
Structure A0A0H3GRX1
Pocket Pocket 1
ColabFold model
FPocket 0.68 · Pocket 9
P2Rank 0.253 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
311 339 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
407 427 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
65 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
351 373 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
162 179 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
383 405 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
116 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
317 339 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
207 266 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
384 406 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 425 PANTHER PTHR30462 UNCHARACTERIZED
162 179 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
180 184 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
292 310 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
185 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 65 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
340 350 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
379 383 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 417 NCBIfam TIGR00155 PqiA/YebS family transporter subunit
19 417 InterPro IPR005219 Intermembrane transport protein PqiA-like, proteobacteria
142 161 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
351 378 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
85 115 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
267 291 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
263 418 Pfam PF04403 Paraquat-inducible protein A
263 418 InterPro IPR007498 Intermembrane transport protein PqiA-like
67 217 Pfam PF04403 Paraquat-inducible protein A
67 217 InterPro IPR007498 Intermembrane transport protein PqiA-like
212 260 SUPERFAMILY SSF48695 Multiheme cytochromes
212 260 InterPro IPR036280 Multiheme cytochrome superfamily
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01593
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.702
27 0.391

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.29 0.177
2 4.19 0.17
3 4.0 0.159
4 1.83 0.035
5 1.43 0.018