Protein profile

KP13_01591

ProP effector

Genome: KpKP13

Gene: AHE43884.1 proQ Structure source: AlphaFold + ColabFold UniProt A0A0H3GVD5
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Amino acids 225
Annotations 5
Features 18
PDB binders 0
Druggability 0.378

Overview

Basic information about this protein and its source genome.

Accession
KP13_01591
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43884.1 proQ
Status
annotated
Amino acids
225
Structure source
AlphaFold + ColabFold
GO
GO:0034057 Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. GO:0010608 Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. GO:0033592 An activity that facilitates the formation of a complementary double-stranded RNA molecule. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
77.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.378
Structure A0A0H3GVD5
Pocket Pocket 3
P2Rank 0.188
Structure A0A0H3GVD5
Pocket Pocket 1
ColabFold model
FPocket 0.141 · Pocket 10
P2Rank 0.181 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0034057 Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity.
  • GO:0010608 Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
  • GO:0033592 An activity that facilitates the formation of a complementary double-stranded RNA molecule.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 119 FunFam G3DSA:1.10.1710.10:FF:000001 RNA chaperone ProQ
5 119 SUPERFAMILY SSF48657 FinO-like
5 119 InterPro IPR036442 ProQ/FinO domain superfamily
5 119 SMART SM00945 ProQ_a_2
5 119 InterPro IPR016103 ProQ/FinO domain
107 169 MobiDBLite mobidb-lite consensus disorder prediction
176 225 Pfam PF17516 ProQ C-terminal domain
176 225 InterPro IPR035236 RNA chaperone ProQ, C-terminal
3 224 Hamap MF_00749 RNA chaperone ProQ [proQ].
3 224 InterPro IPR023529 RNA chaperone ProQ
1 225 PANTHER PTHR38106 RNA CHAPERONE PROQ
1 225 InterPro IPR023529 RNA chaperone ProQ
8 115 Pfam PF04352 ProQ/FINO family
8 115 InterPro IPR016103 ProQ/FinO domain
1 120 Gene3D G3DSA:1.10.1710.10 ProQ/FinO domain
1 120 InterPro IPR036442 ProQ/FinO domain superfamily
132 169 MobiDBLite mobidb-lite consensus disorder prediction
89 123 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVD5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01591
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.378

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.44 0.124