Protein profile

KP13_01590

Tail-specific protease

Genome: KpKP13

Gene: prc AHE43885.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ33
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Amino acids 682
Annotations 8
Features 40
PDB binders 1
Druggability 0.168

Overview

Basic information about this protein and its source genome.

Accession
KP13_01590
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
prc AHE43885.1
Status
annotated
Amino acids
682
Structure source
AlphaFold + ColabFold
EC
3.4.21.102
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515 Binding to a protein. GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.909
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.168
Structure A0A0H3GQ33
Pocket Pocket 13
P2Rank 0.584
Structure A0A0H3GQ33
Pocket Pocket 1
ColabFold model
FPocket 0.362 · Pocket 23
P2Rank 0.673 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 137 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0005515 Binding to a protein.
  • GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
341 528 Gene3D G3DSA:3.90.226.10 -
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
194 551 NCBIfam TIGR00225 C-terminal processing peptidase
194 551 InterPro IPR004447 C-terminal-processing peptidase S41A
633 656 MobiDBLite mobidb-lite consensus disorder prediction
536 667 Pfam PF11818 C-terminal domain of tail specific protease (DUF3340)
536 667 InterPro IPR020992 Tail specific protease, C-terminal
238 308 ProSiteProfiles PS50106 PDZ domain profile.
238 308 InterPro IPR001478 PDZ domain
246 340 Gene3D G3DSA:2.30.42.10 -
246 340 InterPro IPR036034 PDZ superfamily
246 340 FunFam G3DSA:2.30.42.10:FF:000083 Tail-specific protease
245 337 CDD cd00988 PDZ_CTP_protease
23 682 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
49 232 Pfam PF17804 Tail specific protease N-terminal domain
49 232 InterPro IPR040573 Tail specific protease, N-terminal domain
341 493 FunFam G3DSA:3.90.226.10:FF:000015 Periplasmic tail-specific protease
219 343 SUPERFAMILY SSF50156 PDZ domain-like
219 343 InterPro IPR036034 PDZ superfamily
633 655 MobiDBLite mobidb-lite consensus disorder prediction
194 538 SUPERFAMILY SSF52096 ClpP/crotonase
194 538 InterPro IPR029045 ClpP/crotonase-like domain superfamily
181 506 Gene3D G3DSA:3.30.750.44 -
614 634 Coils Coil Coil
356 531 CDD cd07560 Peptidase_S41_CPP
356 531 InterPro IPR004447 C-terminal-processing peptidase S41A
246 323 SMART SM00228 pdz_new
246 323 InterPro IPR001478 PDZ domain
240 320 Pfam PF00595 PDZ domain
240 320 InterPro IPR001478 PDZ domain
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
152 556 PANTHER PTHR32060 TAIL-SPECIFIC PROTEASE
356 528 Pfam PF03572 Peptidase family S41
356 528 InterPro IPR005151 Tail specific protease
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
326 531 SMART SM00245 tsp_4
326 531 InterPro IPR005151 Tail specific protease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ33
AlphaFold — — full sequence — Viewing
ColabFold KP13_01590
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.14 0.371
2 2.74 0.083
3 1.2 0.011

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
TMO
6VBB
A0A1E3M7A1 75.1 Da LogP 0.19 TPSA 23.1 ✓ Ro5 ✓ Clean C[N+](C)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.