Protein profile

KP13_12882

Major facilitator superfamily transporter

Genome: KpKP13

Gene: ANJ86606.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRW6
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Amino acids 456
Annotations 2
Features 60
PDB binders 0
Druggability 0.831

Overview

Basic information about this protein and its source genome.

Accession
KP13_12882
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86606.1
Status
annotated
Amino acids
456
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.831
Structure A0A0H3GRW6
Pocket Pocket 2
P2Rank 0.869
Structure A0A0H3GRW6
Pocket Pocket 1
ColabFold model
FPocket 0.304 · Pocket 3
P2Rank 0.922 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 228 / 4744 genomes with a hit
Normalized 0.048

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
15 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
429 450 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
53 75 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
192 202 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
269 295 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
82 104 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 191 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
22 412 Pfam PF07690 Major Facilitator Superfamily
22 412 InterPro IPR011701 Major facilitator superfamily
424 428 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
306 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 249 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
307 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 451 SUPERFAMILY SSF103473 MFS general substrate transporter
9 451 InterPro IPR036259 MFS transporter superfamily
451 456 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 451 CDD cd17321 MFS_MMR_MDR_like
86 104 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
116 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
382 401 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 447 PANTHER PTHR42718 MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC
144 166 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
329 334 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 454 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
17 454 InterPro IPR020846 Major facilitator superfamily domain
134 144 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
402 423 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
51 74 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 14 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
109 131 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
305 329 PRINTS PR01036 Tetracycline resistance protein TetB signature
20 44 PRINTS PR01036 Tetracycline resistance protein TetB signature
111 131 PRINTS PR01036 Tetracycline resistance protein TetB signature
403 422 PRINTS PR01036 Tetracycline resistance protein TetB signature
141 165 PRINTS PR01036 Tetracycline resistance protein TetB signature
205 227 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
269 291 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
333 355 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 258 FunFam G3DSA:1.20.1720.10:FF:000011 Transporter, major facilitator family
105 115 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
264 455 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
264 455 InterPro IPR036259 MFS transporter superfamily
203 226 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
250 268 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
18 250 Gene3D G3DSA:1.20.1720.10 Multidrug resistance protein D
363 381 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 85 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
166 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
335 357 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
227 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
401 423 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 249 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 50 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
264 455 FunFam G3DSA:1.20.1250.20:FF:000168 Transporter, major facilitator family
358 362 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
171 193 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
296 306 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
430 452 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRW6
AlphaFold — — full sequence — Viewing
ColabFold KP13_12882
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.831
28 0.793

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.85 0.628
2 6.22 0.311
3 6.07 0.3
4 4.51 0.193
5 3.46 0.125

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

60 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
4YH A0R5K5 — 454.6 Da LogP 5.09 TPSA 64.0 1 viol. ✓ Clean CC(C)C(CCCN(C)CCc1ccc(c(c1)OC)OC)(C#N)c2ccc(c(c…
CHEMBL1502567 A0R5K5 — 196.2 Da LogP 1.85 TPSA 34.4 ✓ Ro5 ✓ Clean O=c1c2ccccc2nc2ccccn12
CHEMBL224214 A0R5K5 — 204.6 Da LogP 2.16 TPSA 72.0 ✓ Ro5 Alert N#CC(C#N)=NNc1cccc(Cl)c1
CHEMBL4164617 A0R5K5 — 265.1 Da LogP 3.15 TPSA 34.4 ✓ Ro5 ✓ Clean O=c1c2cccc(Cl)c2nc2c(Cl)cccn12
CHEMBL4168026 A0R5K5 — 232.2 Da LogP 2.13 TPSA 34.4 ✓ Ro5 ✓ Clean O=c1c2ccccc2nc2c(F)cc(F)cn12
CHEMBL4169953 A0R5K5 — 244.7 Da LogP 2.81 TPSA 34.4 ✓ Ro5 ✓ Clean Cc1cccn2c(=O)c3cccc(Cl)c3nc12
CHEMBL4171005 A0R5K5 — 230.7 Da LogP 2.50 TPSA 34.4 ✓ Ro5 ✓ Clean O=c1c2ccc(Cl)cc2nc2ccccn12
CHEMBL4171337 A0R5K5 — 210.2 Da LogP 2.16 TPSA 34.4 ✓ Ro5 ✓ Clean Cc1cccn2c(=O)c3ccccc3nc12
CHEMBL4172500 A0R5K5 — 248.6 Da LogP 2.64 TPSA 34.4 ✓ Ro5 ✓ Clean O=c1c2cccc(Cl)c2nc2ccc(F)cn12
CHEMBL4172832 A0R5K5 — 228.2 Da LogP 2.30 TPSA 34.4 ✓ Ro5 ✓ Clean Cc1ccn2c(=O)c3cccc(F)c3nc2c1

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.