Protein profile

KP13_01580

putative inner membrane protein

Genome: KpKP13

Gene: AHE43895.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H004
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Amino acids 188
Annotations 2
Features 26
PDB binders 0
Druggability 0.463

Overview

Basic information about this protein and its source genome.

Accession
KP13_01580
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43895.1
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.34

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.463
Structure A0A0H3H004
Pocket Pocket 9
P2Rank 0.046
Structure A0A0H3H004
Pocket Pocket 1
ColabFold model
FPocket 0.643 · Pocket 2
P2Rank 0.012 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
128 132 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
20 67 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 185 Hamap MF_01521 Probable manganese efflux pump MntP [mntP].
1 185 InterPro IPR022929 Putative manganese efflux pump MntP
133 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
168 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
12 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
166 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 188 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 182 Pfam PF02659 Putative manganese efflux pump
31 182 InterPro IPR003810 Putative manganese efflux pump
106 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
136 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
155 165 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
107 129 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 185 PANTHER PTHR35529 MANGANESE EFFLUX PUMP MNTP-RELATED
1 185 InterPro IPR003810 Putative manganese efflux pump
87 105 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
68 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H004
AlphaFold — — full sequence — Viewing
ColabFold KP13_01580
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.463

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.33 0.015