Protein profile

KP13_01574

putative inner membrane protein

Genome: KpKP13

Gene: AHE43900.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZZ9
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Amino acids 519
Annotations 3
Features 44
PDB binders 0
Druggability 0.991

Overview

Basic information about this protein and its source genome.

Accession
KP13_01574
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43900.1
Status
annotated
Amino acids
519
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.32
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
78.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.991
Structure A0A0H3GZZ9
Pocket Pocket 45
P2Rank 0.722
Structure A0A0H3GZZ9
Pocket Pocket 1
ColabFold model
FPocket 0.983 · Pocket 1
P2Rank 0.468 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 153 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records
Show feature table
Start End DB Term Name
154 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
281 433 Gene3D G3DSA:3.10.580.10 -
281 433 InterPro IPR046342 CBS domain superfamily
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 183 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
85 102 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
149 153 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
281 433 FunFam G3DSA:3.10.580.10:FF:000008 Integral membrane protein TerC
432 518 SUPERFAMILY SSF56176 FAD-binding/transporter-associated domain-like
432 518 InterPro IPR036318 FAD-binding, type PCMH-like superfamily
208 212 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
367 427 ProSiteProfiles PS51371 CBS domain profile.
367 427 InterPro IPR000644 CBS domain
37 47 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
304 363 ProSiteProfiles PS51371 CBS domain profile.
304 363 InterPro IPR000644 CBS domain
213 231 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
432 509 Pfam PF03471 Transporter associated domain
432 509 InterPro IPR005170 Transporter-associated domain
48 69 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 203 Pfam PF03741 Integral membrane protein TerC family
14 203 InterPro IPR005496 Integral membrane protein TerC
299 416 CDD cd04590 CBS_pair_CorC_HlyC_assoc
299 416 InterPro IPR044751 Ion transporter-like, CBS domain
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
434 510 Gene3D G3DSA:3.30.465.10 -
434 510 InterPro IPR016169 FAD-binding, type PCMH, subdomain 2
70 80 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
288 422 SUPERFAMILY SSF54631 CBS-domain pair
288 422 InterPro IPR046342 CBS domain superfamily
122 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
185 207 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 207 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
431 512 SMART SM01091 CorC_HlyC_2
431 512 InterPro IPR005170 Transporter-associated domain
212 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 121 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
123 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 510 PANTHER PTHR22777 HEMOLYSIN-RELATED
232 519 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZZ9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01574
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
45 0.991
5 0.605

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.53 0.396
2 7.44 0.39
3 3.25 0.113