Protein profile

KP13_01565

hypothetical protein

Genome: KpKP13

Gene: AHE43907.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZY8
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Amino acids 207
Annotations 1
Features 14
PDB binders 0
Druggability 0.368

Overview

Basic information about this protein and its source genome.

Accession
KP13_01565
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43907.1
Status
annotated
Amino acids
207
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.04
DEG E-value
3.88e-37
Localization
OuterMembrane
ColabFold pLDDT
76.86

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.368
Structure A0A0H3GZY8
Pocket Pocket 4
P2Rank
Structure A0A0H3GZY8
Pocket No pockets
ColabFold model
FPocket 0.535 · Pocket 7
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 97 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 34 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
34 186 Pfam PF03843 Outer membrane lipoprotein Slp family
34 186 InterPro IPR004658 Outer membrane lipoprotein Slp
25 202 PANTHER PTHR37530 OUTER MEMBRANE PROTEIN SLP
25 202 InterPro IPR004658 Outer membrane lipoprotein Slp
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
24 201 NCBIfam TIGR00752 Slp family lipoprotein
24 201 InterPro IPR004658 Outer membrane lipoprotein Slp
40 207 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 204 PIRSF PIRSF004982 SlP
19 204 InterPro IPR004658 Outer membrane lipoprotein Slp

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZY8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01565
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.368
3 0.263