Protein profile

KP13_01562

Cell division topological specificity factor

Genome: KpKP13

Gene: minE AHE43910.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVA9
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Amino acids 89
Annotations 3
Features 11
PDB binders 0
Druggability 0.514

Overview

Basic information about this protein and its source genome.

Accession
KP13_01562
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
minE AHE43910.1
Status
annotated
Amino acids
89
Structure source
AlphaFold + ColabFold
GO
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032955 Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0042802 Binding to an identical protein or proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.318
DEG E-value
1.53e-57
Localization
Cytoplasmic
ColabFold pLDDT
77.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.514
Structure A0A0H3GVA9
Pocket Pocket 11
P2Rank
Structure A0A0H3GVA9
Pocket No pockets
ColabFold model
FPocket 0.851 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 135 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0032955 Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
  • GO:0042802 Binding to an identical protein or proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 83 Gene3D G3DSA:3.30.1070.10 Cell division topological specificity factor MinE
1 83 InterPro IPR036707 Cell division topological specificity factor MinE superfamily
14 82 Pfam PF03776 Septum formation topological specificity factor MinE
14 82 InterPro IPR005527 Cell division topological specificity factor MinE
1 83 NCBIfam TIGR01215 cell division topological specificity factor MinE
1 83 InterPro IPR005527 Cell division topological specificity factor MinE
3 86 Hamap MF_00262 Cell division topological specificity factor [minE].
3 86 InterPro IPR005527 Cell division topological specificity factor MinE
32 85 SUPERFAMILY SSF55229 Cell division protein MinE topological specificity domain
32 85 InterPro IPR036707 Cell division topological specificity factor MinE superfamily
1 83 FunFam G3DSA:3.30.1070.10:FF:000001 Cell division topological specificity factor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVA9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01562
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.514
1 0.054
3 0.031
2 0.002