Protein profile

KP13_01554

Na(+)/H(+) antiporter nhaB

Genome: KpKP13

Gene: AHE43917.1 nhaB Structure source: AlphaFold + ColabFold UniProt A0A0H3GUN0
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Amino acids 576
Annotations 4
Features 49
PDB binders 0
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
KP13_01554
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43917.1 nhaB
Status
annotated
Amino acids
576
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure A0A0H3GUN0
Pocket Pocket 5
P2Rank 0.487
Structure A0A0H3GUN0
Pocket Pocket 1
ColabFold model
FPocket 0.958 · Pocket 1
P2Rank 0.608 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 139 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
144 148 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
538 560 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 109 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
258 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
207 225 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
76 555 PANTHER PTHR43302 TRANSPORTER ARSB-RELATED
561 576 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
376 380 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
381 398 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
226 257 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
62 572 NCBIfam TIGR00774 Na(+)/H(+) antiporter NhaB
62 572 InterPro IPR004671 Na+/H+ antiporter NhaB
298 320 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
399 409 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
121 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
357 375 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
202 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
60 576 Hamap MF_01599 Na(+)/H(+) antiporter NhaB [nhaB].
60 576 InterPro IPR004671 Na+/H+ antiporter NhaB
410 428 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
429 512 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
298 320 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
359 391 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
513 532 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 571 Pfam PF06450 Bacterial Na+/H+ antiporter B (NhaB)
62 571 InterPro IPR004671 Na+/H+ antiporter NhaB
182 204 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
169 179 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
180 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
258 278 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
539 561 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
279 297 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
208 225 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
321 356 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
449 471 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
149 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
513 531 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
532 537 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
406 428 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUN0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01554
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.843
15 0.206

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.73 0.467
2 7.15 0.372
3 7.01 0.363
4 4.8 0.213
5 4.74 0.209