Protein profile

KP13_01539

Proteasome subunit alpha/beta domain-containing protein

Genome: KpKP13

Gene: AHE43932.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUL5
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Amino acids 242
Annotations 2
Features 6
PDB binders 0
Druggability 0.458

Overview

Basic information about this protein and its source genome.

Accession
KP13_01539
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43932.1
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:0005839 A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603 OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.458
Structure A0A0H3GUL5
Pocket Pocket 2
P2Rank 0.148
Structure A0A0H3GUL5
Pocket Pocket 1
ColabFold model
FPocket 0.516 · Pocket 15
P2Rank 0.675 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 44 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005839 A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
  • GO:0051603 OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
2 233 SUPERFAMILY SSF56235 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
2 233 InterPro IPR029055 Nucleophile aminohydrolases, N-terminal
1 241 PIRSF PIRSF009120 UCP009120_prtse
1 241 InterPro IPR016545 Uncharacterised conserved protein UCP009120, proteasome-type protease, Sll0069
1 210 Gene3D G3DSA:3.60.20.10 Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
1 210 InterPro IPR029055 Nucleophile aminohydrolases, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUL5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01539
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.458

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.57 0.133
2 2.44 0.066
3 1.37 0.016