Protein profile

KP13_01520

Citrate-proton symporter

Genome: KpKP13

Gene: AHE43951.1 citH Structure source: AlphaFold + ColabFold UniProt A6TAT7

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Amino acids 463

Annotations 3

Features 60

PDB binders 0

Druggability 0.656

Overview

Basic information about this protein and its source genome.

Accession: KP13_01520
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE43951.1 citH
Status: annotated
Amino acids: 463
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 86.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.656

Structure A6TAT7

Pocket Pocket 23

P2Rank 0.837

Structure A6TAT7

Pocket Pocket 1

ColabFold model

FPocket 0.917 · Pocket 12

P2Rank 0.74 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 71 / 4744 genomes with a hit

Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records

Show feature table

Start	End	DB	Term	Name
109	119	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
224	240	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	20	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
158	183	ProSitePatterns	PS00217	Sugar transport proteins signature 2.
158	183	InterPro	IPR005829	Sugar transporter, conserved site
63	80	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
271	293	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
49	454	CDD	cd17368	MFS_CitA
48	456	ProSiteProfiles	PS50850	Major facilitator superfamily (MFS) profile.
48	456	InterPro	IPR020846	Major facilitator superfamily domain
435	452	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
337	354	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	83	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
267	457	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
267	457	InterPro	IPR036259	MFS transporter superfamily
121	143	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
36	456	PANTHER	PTHR43528	ALPHA-KETOGLUTARATE PERMEASE
153	175	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
401	423	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
435	453	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
54	400	Pfam	PF07690	Major Facilitator Superfamily
54	400	InterPro	IPR011701	Major facilitator superfamily
142	146	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147	175	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
241	260	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
176	195	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
381	400	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	20	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
326	343	ProSitePatterns	PS00216	Sugar transport proteins signature 1.
326	343	InterPro	IPR005829	Sugar transporter, conserved site
308	330	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
309	330	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
90	112	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
196	218	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
290	308	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
261	289	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
120	141	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
84	108	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
108	124	ProSitePatterns	PS00216	Sugar transport proteins signature 1.
108	124	InterPro	IPR005829	Sugar transporter, conserved site
45	261	FunFam	G3DSA:1.20.1250.20:FF:000001	Dicarboxylate MFS transporter
363	385	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
222	239	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
454	463	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
424	434	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
47	454	SUPERFAMILY	SSF103473	MFS general substrate transporter
47	454	InterPro	IPR036259	MFS transporter superfamily
196	212	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
331	336	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55	445	NCBIfam	TIGR00883	metabolite/H+ symporter
55	445	InterPro	IPR004736	MFS transporter, metabolite:H symporter
337	359	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
355	359	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
360	380	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
213	223	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
41	266	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
41	266	InterPro	IPR036259	MFS transporter superfamily
398	420	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A6TAT7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01520	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
23				0.656
13				0.338

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	13.23	0.678
2	3.06	0.102
3	2.1	0.048
4	2.05	0.045
5	1.3	0.014

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
12				0.917
18				0.288

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	15.63	0.758
2	3.92	0.154
3	2.85	0.09
4	2.66	0.078
5	2.61	0.075