Protein profile

KP13_01519

ABC transporter, periplasmic substrate-binding protein

Genome: KpKP13

Gene: AHE43952.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUJ4
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Amino acids 269
Annotations 2
Features 14
PDB binders 0
Druggability 0.363

Overview

Basic information about this protein and its source genome.

Accession
KP13_01519
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43952.1
Status
annotated
Amino acids
269
Structure source
AlphaFold + ColabFold
GO
GO:0030973 Binding to a molybdate ion (MoO4 2-). GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.363
Structure A0A0H3GUJ4
Pocket Pocket 12
P2Rank 0.285
Structure A0A0H3GUJ4
Pocket Pocket 1
ColabFold model
FPocket 0.675 · Pocket 1
P2Rank 0.234 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030973 Binding to a molybdate ion (MoO4 2-).
  • GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
12 260 PANTHER PTHR30632 MOLYBDATE-BINDING PERIPLASMIC PROTEIN
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
109 216 Gene3D G3DSA:3.40.190.10 -
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
28 252 Gene3D G3DSA:3.40.190.10 -
25 269 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 254 Pfam PF13531 Bacterial extracellular solute-binding protein
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
26 254 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUJ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01519
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.363
7 0.237

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.54 0.071