Protein profile

KP13_31969

Type IV secretion system protein IcmF (I-T4SS)

Genome: KpKP13

Gene: AHE43986.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRJ4
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Amino acids 1129
Annotations 0
Features 17
PDB binders 0
Druggability 0.894

Overview

Basic information about this protein and its source genome.

Accession
KP13_31969
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43986.1
Status
annotated
Amino acids
1129
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
79.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.894
Structure A0A0H3GRJ4
Pocket Pocket 100
P2Rank 0.19
Structure A0A0H3GRJ4
Pocket Pocket 1
ColabFold model
FPocket 0.729 · Pocket 39
P2Rank 0.269 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 21 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
16 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
351 1107 PANTHER PTHR36153 INNER MEMBRANE PROTEIN-RELATED
12 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
409 725 Pfam PF06761 Intracellular multiplication and human macrophage-killing
409 725 InterPro IPR009612 IcmF-related
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
362 383 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
981 1087 Pfam PF06744 Type VI secretion protein IcmF C2-like domain
981 1087 InterPro IPR010623 Type VI secretion system IcmF, C-terminal
361 383 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
384 1129 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 361 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRJ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_31969
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
100 0.894

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.97 0.097
2 2.34 0.061
3 1.38 0.017
4 0.73 0.002