Protein profile

KP13_01475

ImpA domain-containing protein

Genome: KpKP13

Gene: AHE43991.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRI9
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Amino acids 471
Annotations 0
Features 12
PDB binders 0
Druggability 0.832

Overview

Basic information about this protein and its source genome.

Accession
KP13_01475
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43991.1
Status
annotated
Amino acids
471
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
75.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.832
Structure A0A0H3GRI9
Pocket Pocket 4
P2Rank 0.054
Structure A0A0H3GRI9
Pocket Pocket 1
ColabFold model
FPocket 0.251 · Pocket 14
P2Rank 0.12 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
176 237 MobiDBLite mobidb-lite consensus disorder prediction
248 269 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
303 447 Pfam PF12486 Type VI secretion system, EvfB, or VasL
303 447 InterPro IPR021069 ImpA, C-terminal
133 153 Coils Coil Coil
8 418 PANTHER PTHR37024 TYPE VI SECRETION SYSTEM DUF2094 AND IMPA-RELATED DOMAIN PROTEIN
205 219 MobiDBLite mobidb-lite consensus disorder prediction
1 247 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
270 471 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 112 Pfam PF06812 ImpA, N-terminal, type VI secretion system
8 112 InterPro IPR010657 ImpA, N-terminal
247 269 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRI9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01475
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.832
1 0.642
30 0.391

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.44 0.066
2 1.14 0.009
3 1.11 0.008