Protein profile

KP13_04721

Nitrate transport protein nrtA

Genome: KpKP13

Gene: AHE44014.1 nrtA Structure source: AlphaFold + ColabFold UniProt A0A0H3GZJ8
Export view
Amino acids 441
Annotations 1
Features 9
PDB binders 0
Druggability 0.532

Overview

Basic information about this protein and its source genome.

Accession
KP13_04721
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44014.1 nrtA
Status
annotated
Amino acids
441
Structure source
AlphaFold + ColabFold
GO
GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.532
Structure A0A0H3GZJ8
Pocket Pocket 5
P2Rank 0.063
Structure A0A0H3GZJ8
Pocket Pocket 1
ColabFold model
FPocket 0.174 · Pocket 10
P2Rank 0.038 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 64 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
40 400 PANTHER PTHR30024 ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
68 293 CDD cd13553 PBP2_NrtA_CpmA_like
68 293 InterPro IPR044527 Nitrate/bicarbonate ABC transporter substrate-binding domain
1 57 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 57 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
61 312 Pfam PF13379 NMT1-like family
68 420 Gene3D G3DSA:3.40.190.10 -
153 431 Gene3D G3DSA:3.40.190.10 -
65 304 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZJ8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04721
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.019
11 0.004
2 0.001
7 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.64 0.063
2 1.57 0.02
3 1.42 0.015
4 1.26 0.011