Protein profile

KP13_04710

Respiratory nitrate reductase 1 delta chain

Genome: KpKP13

Gene: narJ AHE44025.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPN0
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Amino acids 236
Annotations 5
Features 10
PDB binders 0
Druggability 0.645

Overview

Basic information about this protein and its source genome.

Accession
KP13_04710
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
narJ AHE44025.1
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082 Binding to an unfolded protein. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016530 Binding to and delivering metal ions to a target protein. GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.657
DEG E-value
4.47e-99
Localization
Cytoplasmic
ColabFold pLDDT
85.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.645
Structure A0A0H3GPN0
Pocket Pocket 1
P2Rank 0.375
Structure A0A0H3GPN0
Pocket Pocket 1
ColabFold model
FPocket 0.12 · Pocket 10
P2Rank 0.339 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 96 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016530 Binding to and delivering metal ions to a target protein.
  • GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
8 161 NCBIfam TIGR00684 nitrate reductase molybdenum cofactor assembly chaperone
8 161 InterPro IPR003765 Nitrate reductase chaperone, NarJ
3 235 PANTHER PTHR43680 NITRATE REDUCTASE MOLYBDENUM COFACTOR ASSEMBLY CHAPERONE
3 235 InterPro IPR003765 Nitrate reductase chaperone, NarJ
5 149 Gene3D G3DSA:1.10.3480.10 -
5 163 SUPERFAMILY SSF89155 TorD-like
5 163 InterPro IPR036411 TorD-like superfamily
44 130 Pfam PF02613 Nitrate reductase delta subunit
44 130 InterPro IPR020945 DMSO/Nitrate reductase chaperone
5 151 FunFam G3DSA:1.10.3480.10:FF:000001 Nitrate reductase molybdenum cofactor assembly chaperone

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPN0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04710
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.645

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.09 0.368
2 2.52 0.07
3 1.18 0.01