Protein profile

KP13_04694

Oligopeptide transport system permease protein oppC

Genome: KpKP13

Gene: AHE44047.1 oppC Structure source: AlphaFold + ColabFold UniProt A0A0H3GU93
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Amino acids 302
Annotations 5
Features 33
PDB binders 0
Druggability 0.74

Overview

Basic information about this protein and its source genome.

Accession
KP13_04694
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44047.1 oppC
Status
annotated
Amino acids
302
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.371
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.74
Structure A0A0H3GU93
Pocket Pocket 4
P2Rank 0.057
Structure A0A0H3GU93
Pocket Pocket 1
ColabFold model
FPocket 0.729 · Pocket 11
P2Rank 0.08 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 145 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
138 160 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
100 283 SUPERFAMILY SSF161098 MetI-like
100 283 InterPro IPR035906 MetI-like superfamily
248 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 301 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
140 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
100 298 Gene3D G3DSA:1.10.3720.10 -
100 298 InterPro IPR035906 MetI-like superfamily
100 298 FunFam G3DSA:1.10.3720.10:FF:000008 Oligopeptide ABC transporter permease OppC
268 290 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 290 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
101 290 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
159 163 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
184 217 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
164 183 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 76 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
24 76 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
129 139 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
214 236 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 290 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 283 CDD cd06261 TM_PBP2
117 283 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
40 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
218 247 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
164 183 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 128 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 39 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40 62 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
119 300 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
119 300 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
291 302 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU93
AlphaFold — — full sequence — Viewing
ColabFold KP13_04694
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.74

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.83 0.088
2 2.71 0.081
3 1.99 0.042
4 1.43 0.019
5 1.13 0.008