Protein profile

KP13_04689

Cardiolipin synthase

Genome: KpKP13

Gene: AHE44052.1 cls Structure source: AlphaFold + ColabFold UniProt A0A0H3GU90
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Amino acids 486
Annotations 6
Features 32
PDB binders 0
Druggability 0.412

Overview

Basic information about this protein and its source genome.

Accession
KP13_04689
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44052.1 cls
Status
annotated
Amino acids
486
Structure source
AlphaFold + ColabFold
EC
2.7.8.-
GO
GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0016780 Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.412
Structure A0A0H3GU90
Pocket Pocket 5
P2Rank 0.718
Structure A0A0H3GU90
Pocket Pocket 1
ColabFold model
FPocket 0.942 · Pocket 34
P2Rank 0.73 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 127 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.
  • GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
  • GO:0016780 Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
59 486 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
219 246 ProSiteProfiles PS50035 Phospholipase D phosphodiesterase active site profile.
219 246 InterPro IPR001736 Phospholipase D/Transphosphatidylase
399 426 ProSiteProfiles PS50035 Phospholipase D phosphodiesterase active site profile.
399 426 InterPro IPR001736 Phospholipase D/Transphosphatidylase
27 486 PANTHER PTHR21248 CARDIOLIPIN SYNTHASE
23 59 Pfam PF13396 Phospholipase_D-nuclease N-terminal
23 59 InterPro IPR027379 Cardiolipin synthase N-terminal
113 298 FunFam G3DSA:3.30.870.10:FF:000002 Cardiolipin synthase A
134 242 Pfam PF13091 PLD-like domain
134 242 InterPro IPR025202 Phospholipase D-like domain
332 444 Pfam PF13091 PLD-like domain
332 444 InterPro IPR025202 Phospholipase D-like domain
6 25 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 315 SUPERFAMILY SSF56024 Phospholipase D/nuclease
10 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 297 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
316 458 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
316 458 FunFam G3DSA:3.30.870.10:FF:000003 Cardiolipin synthase A
6 486 NCBIfam TIGR04265 cardiolipin synthase
6 486 InterPro IPR022924 Cardiolipin synthase
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 36 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
37 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 281 CDD cd09152 PLDc_EcCLS_like_1
219 246 SMART SM00155 pld_4
399 426 SMART SM00155 pld_4
274 473 SUPERFAMILY SSF56024 Phospholipase D/nuclease
36 58 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
311 484 CDD cd09158 PLDc_EcCLS_like_2
2 486 Hamap MF_00190 Cardiolipin synthase A [clsA].
2 486 InterPro IPR030840 Cardiolipin synthase A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU90
AlphaFold — — full sequence — Viewing
ColabFold KP13_04689
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.412
11 0.403

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.24 0.679
2 7.27 0.379
3 1.57 0.024
4 1.38 0.017