Protein profile

KP13_04684

Protein tonB

Genome: KpKP13

Gene: AHE44057.1 tonB Structure source: AlphaFold + ColabFold UniProt A0A0H3GUY2
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Amino acids 245
Annotations 6
Features 23
PDB binders 0
Druggability 0.038

Overview

Basic information about this protein and its source genome.

Accession
KP13_04684
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44057.1 tonB
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. GO:0098797 Any protein complex that is part of the plasma membrane. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.355
DEG E-value
6.209999999999999e-89
Localization
Unknown
ColabFold pLDDT
75.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.038
Structure A0A0H3GUY2
Pocket Pocket 6
P2Rank 0.005
Structure A0A0H3GUY2
Pocket Pocket 1
ColabFold model
FPocket 0.379 · Pocket 7
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 73 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.
  • GO:0098797 Any protein complex that is part of the plasma membrane.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
106 123 MobiDBLite mobidb-lite consensus disorder prediction
158 244 Gene3D G3DSA:3.30.2420.10 TonB
160 228 SUPERFAMILY SSF74653 TolA/TonB C-terminal domain
49 167 MobiDBLite mobidb-lite consensus disorder prediction
167 237 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal
167 237 InterPro IPR037682 TonB, C-terminal
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
33 164 Pfam PF16031 TonB polyproline region
8 240 PANTHER PTHR33446 PROTEIN TONB-RELATED
168 240 NCBIfam TIGR01352 TonB family C-terminal domain
168 240 InterPro IPR006260 TonB/TolA, C-terminal
56 70 MobiDBLite mobidb-lite consensus disorder prediction
33 245 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
162 183 PRINTS PR01374 Gram-negative bacterial tonB protein signature
162 183 InterPro IPR003538 Gram-negative bacterial TonB protein
97 107 PRINTS PR01374 Gram-negative bacterial tonB protein signature
97 107 InterPro IPR003538 Gram-negative bacterial TonB protein
202 219 PRINTS PR01374 Gram-negative bacterial tonB protein signature
202 219 InterPro IPR003538 Gram-negative bacterial TonB protein
183 201 PRINTS PR01374 Gram-negative bacterial tonB protein signature
183 201 InterPro IPR003538 Gram-negative bacterial TonB protein
129 153 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUY2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04684
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.12 0.008