Protein profile

KP13_04671

Integration host factor subunit alpha

Genome: KpKP13

Gene: AHE44069.1 ihfA Structure source: AlphaFold + ColabFold UniProt A0A0H3GPK1
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Amino acids 99
Annotations 4
Features 26
PDB binders 0
Druggability 0.673

Overview

Basic information about this protein and its source genome.

Accession
KP13_04671
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44069.1 ihfA
Status
annotated
Amino acids
99
Structure source
AlphaFold + ColabFold
GO
GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
98.99
DEG E-value
5.0000000000000005e-68
Localization
Cytoplasmic
ColabFold pLDDT
96.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.673
Structure A0A0H3GPK1
Pocket Pocket 1
P2Rank 0.016
Structure A0A0H3GPK1
Pocket Pocket 1
ColabFold model
FPocket 0.552 · Pocket 4
P2Rank 0.039 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 235 / 4744 genomes with a hit
Normalized 0.05

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
4 91 CDD cd13835 IHF_A
4 91 InterPro IPR005684 Integration host factor, alpha subunit
1 97 Hamap MF_00380 Integration host factor subunit alpha [ihfA].
1 97 InterPro IPR005684 Integration host factor, alpha subunit
3 93 SUPERFAMILY SSF47729 IHF-like DNA-binding proteins
3 93 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
1 92 PANTHER PTHR33175 DNA-BINDING PROTEIN HU
1 92 InterPro IPR000119 Histone-like DNA-binding protein
3 92 SMART SM00411 bhlneu
3 92 InterPro IPR000119 Histone-like DNA-binding protein
76 90 PRINTS PR01727 Prokaryotic integration host factor signature
76 90 InterPro IPR000119 Histone-like DNA-binding protein
42 57 PRINTS PR01727 Prokaryotic integration host factor signature
42 57 InterPro IPR000119 Histone-like DNA-binding protein
60 73 PRINTS PR01727 Prokaryotic integration host factor signature
60 73 InterPro IPR000119 Histone-like DNA-binding protein
52 75 MobiDBLite mobidb-lite consensus disorder prediction
1 99 Gene3D G3DSA:4.10.520.10 -
1 99 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
1 98 FunFam G3DSA:4.10.520.10:FF:000002 Integration host factor subunit alpha
48 67 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature.
48 67 InterPro IPR020816 Histone-like DNA-binding protein, conserved site
3 91 Pfam PF00216 Bacterial DNA-binding protein
3 91 InterPro IPR000119 Histone-like DNA-binding protein
2 97 NCBIfam TIGR00987 integration host factor subunit alpha
2 97 InterPro IPR005684 Integration host factor, alpha subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPK1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04671
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.673
8 0.603
4 0.256

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.1 0.104