Protein profile

KP13_04658

hypothetical protein

Genome: KpKP13

Gene: AHE44082.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU67
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Amino acids 280
Annotations 7
Features 6
PDB binders 0
Druggability 0.965

Overview

Basic information about this protein and its source genome.

Accession
KP13_04658
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44082.1
Status
annotated
Amino acids
280
Structure source
AlphaFold + ColabFold
EC
2.7.11.33 2.7.4.28
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0043531 Binding to ADP, adenosine 5'-diphosphate. GO:0016776 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.97
DEG E-value
1.14e-87
Localization
Cytoplasmic
ColabFold pLDDT
89.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.965
Structure A0A0H3GU67
Pocket Pocket 1
P2Rank 0.348
Structure A0A0H3GU67
Pocket Pocket 1
ColabFold model
FPocket 0.271 · Pocket 10
P2Rank 0.497 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 5 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

5
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
  • GO:0043531 Binding to ADP, adenosine 5'-diphosphate.
  • GO:0016776 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).
  • GO:0004674 Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
9 279 Hamap MF_01062 Phosphoenolpyruvate synthase regulatory protein [ppsR].
9 279 InterPro IPR026530 Phosphoenolpyruvate synthase regulatory protein
12 270 Pfam PF03618 Kinase/pyrophosphorylase
12 270 InterPro IPR005177 Bifunctional kinase-pyrophosphorylase
5 277 PANTHER PTHR31756 PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC
5 277 InterPro IPR005177 Bifunctional kinase-pyrophosphorylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU67
AlphaFold — — full sequence — Viewing
ColabFold KP13_04658
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.965

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.35 0.182
2 1.6 0.025