Protein profile

KP13_04642

putative HTH-type transcriptional regulator ltrA

Genome: KpKP13

Gene: AHE44098.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUV7
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Amino acids 303
Annotations 4
Features 19
PDB binders 4
Druggability 0.753

Overview

Basic information about this protein and its source genome.

Accession
KP13_04642
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44098.1
Status
annotated
Amino acids
303
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351 The synthesis of an RNA transcript from a DNA template.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753
Structure A0A0H3GUV7
Pocket Pocket 22
P2Rank 0.888
Structure A0A0H3GUV7
Pocket Pocket 1
ColabFold model
FPocket 0.953 · Pocket 2
P2Rank 0.808 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006351 The synthesis of an RNA transcript from a DNA template.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
5 118 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
5 118 InterPro IPR036390 Winged helix DNA-binding domain superfamily
94 293 Pfam PF03466 LysR substrate binding domain
94 293 InterPro IPR005119 LysR, substrate-binding
2 88 Gene3D G3DSA:1.10.10.10 -
2 88 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
93 292 Gene3D G3DSA:3.40.190.290 -
33 43 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
33 43 InterPro IPR000847 Transcription regulator HTH, LysR
43 54 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
43 54 InterPro IPR000847 Transcription regulator HTH, LysR
22 33 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
22 33 InterPro IPR000847 Transcription regulator HTH, LysR
5 62 ProSiteProfiles PS50931 LysR-type HTH domain profile.
5 62 InterPro IPR000847 Transcription regulator HTH, LysR
95 296 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
6 293 PANTHER PTHR30126 HTH-TYPE TRANSCRIPTIONAL REGULATOR
8 65 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
8 65 InterPro IPR000847 Transcription regulator HTH, LysR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUV7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04642
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.753
3 0.421

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.77 0.808

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CCU
3GLB
P07774 142.1 Da LogP 0.27 TPSA 74.6 ✓ Ro5 ✓ Clean C(=C/C(=O)O)/C=C\C(=O)O
FLC
5ZZO
A0A0D1IHL7 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
PCI
4RPN
P52679 266.3 Da LogP 4.66 TPSA 20.2 ✓ Ro5 ✓ Clean c1(c(c(c(c(c1Cl)Cl)Cl)Cl)Cl)O
T6C
4RPO
P52679 197.4 Da LogP 3.35 TPSA 20.2 ✓ Ro5 ✓ Clean c1c(cc(c(c1Cl)O)Cl)Cl

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.