Protein profile

KP13_04640

putative TetR-family trancriptional regulatory protein

Genome: KpKP13

Gene: AHE44100.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZE1
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Amino acids 178
Annotations 3
Features 12
PDB binders 0
Druggability 0.81

Overview

Basic information about this protein and its source genome.

Accession
KP13_04640
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44100.1
Status
annotated
Amino acids
178
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.237
DEG E-value
3.92e-60
Localization
Unknown
ColabFold pLDDT
91.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.81
Structure A0A0H3GZE1
Pocket Pocket 7
P2Rank 0.709
Structure A0A0H3GZE1
Pocket Pocket 1
ColabFold model
FPocket 0.911 · Pocket 1
P2Rank 0.682 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 50 ProSiteProfiles PS50977 TetR-type HTH domain profile.
1 50 InterPro IPR001647 DNA-binding HTH domain, TetR-type
64 156 Pfam PF17935 Tetracyclin repressor-like, C-terminal domain
64 156 InterPro IPR041478 Tetracyclin repressor-like, C-terminal domain 27
2 67 SUPERFAMILY SSF46689 Homeodomain-like
2 67 InterPro IPR009057 Homeobox-like domain superfamily
1 172 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
4 169 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
63 177 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
63 177 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
4 41 Pfam PF00440 Bacterial regulatory proteins, tetR family
4 41 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZE1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04640
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.81
1 0.733

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.09 0.301
2 4.18 0.17
3 2.76 0.084
4 1.73 0.031