Protein profile

KP13_04639

Multidrug resistance protein mdtA

Genome: KpKP13

Gene: AHE44101.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR78
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Amino acids 369
Annotations 5
Features 19
PDB binders 0
Druggability 0.512

Overview

Basic information about this protein and its source genome.

Accession
KP13_04639
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44101.1
Status
annotated
Amino acids
369
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.512
Structure A0A0H3GR78
Pocket Pocket 4
P2Rank 0.007
Structure A0A0H3GR78
Pocket Pocket 1
ColabFold model
FPocket 0.445 · Pocket 8
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
  • GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
37 356 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
37 356 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
95 168 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
139 166 Coils Coil Coil
54 260 Gene3D G3DSA:2.40.30.170 -
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
51 261 SUPERFAMILY SSF111369 HlyD-like secretion proteins
6 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
60 202 Gene3D G3DSA:2.40.50.100 -
10 359 PANTHER PTHR30469 MULTIDRUG RESISTANCE PROTEIN MDTA
268 356 Gene3D G3DSA:2.40.420.20 -
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
59 261 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
59 261 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
20 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR78
AlphaFold — — full sequence — Viewing
ColabFold KP13_04639
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.512
2 0.002
16 0.002
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.11 0.007