Protein profile

KP13_04636

TetR-family trancriptional regulatory protein

Genome: KpKP13

Gene: AHE44104.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPI4
Export view
Amino acids 210
Annotations 1
Features 17
PDB binders 0
Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession
KP13_04636
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44104.1
Status
annotated
Amino acids
210
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813
Structure A0A0H3GPI4
Pocket Pocket 2
P2Rank
Structure A0A0H3GPI4
Pocket No pockets
ColabFold model
FPocket 0.672 · Pocket 3
P2Rank 0.175 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
9 90 SUPERFAMILY SSF46689 Homeodomain-like
9 90 InterPro IPR009057 Homeobox-like domain superfamily
15 65 Gene3D G3DSA:1.10.10.60 -
20 65 Pfam PF00440 Bacterial regulatory proteins, tetR family
20 65 InterPro IPR001647 DNA-binding HTH domain, TetR-type
71 207 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
20 33 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
20 33 InterPro IPR001647 DNA-binding HTH domain, TetR-type
40 63 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
40 63 InterPro IPR001647 DNA-binding HTH domain, TetR-type
89 206 Pfam PF14246 AefR-like transcriptional repressor, C-terminal domain
89 206 InterPro IPR039536 Transcriptional regulator TetR, C-terminal, Proteobacteria type
1 204 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
14 73 ProSiteProfiles PS50977 TetR-type HTH domain profile.
14 73 InterPro IPR001647 DNA-binding HTH domain, TetR-type
86 203 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
86 203 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPI4
AlphaFold — — full sequence — Viewing
ColabFold KP13_04636
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.813
1 0.478