Protein profile

KP13_04632

FeS cluster assembly protein sufB

Genome: KpKP13

Gene: sufB AHE44108.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR67
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Amino acids 495
Annotations 1
Features 9
PDB binders 0
Druggability 0.666

Overview

Basic information about this protein and its source genome.

Accession
KP13_04632
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sufB AHE44108.1
Status
annotated
Amino acids
495
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.092
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
82.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.666
Structure A0A0H3GR67
Pocket Pocket 14
P2Rank 0.68
Structure A0A0H3GR67
Pocket Pocket 1
ColabFold model
FPocket 0.572 · Pocket 1
P2Rank 0.681 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 735 / 4744 genomes with a hit
Normalized 0.155

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
155 217 Pfam PF19295 SufBD protein N-terminal region
155 217 InterPro IPR045595 SUF system FeS cluster assembly, SufBD, N-terminal
19 495 PANTHER PTHR30508 FES CLUSTER ASSEMBLY PROTEIN SUF
21 486 NCBIfam TIGR01980 Fe-S cluster assembly protein SufB
21 486 InterPro IPR010231 SUF system FeS cluster assembly, SufB
234 466 Pfam PF01458 SUF system FeS cluster assembly, SufBD
234 466 InterPro IPR000825 SUF system FeS cluster assembly, SufBD
41 492 SUPERFAMILY SSF101960 Stabilizer of iron transporter SufD
41 492 InterPro IPR037284 SUF system FeS cluster assembly, SufBD superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR67
AlphaFold — — full sequence — Viewing
ColabFold KP13_04632
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.666
2 0.371

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.8 0.662
2 7.48 0.393
3 6.89 0.355
4 3.93 0.155
5 1.09 0.007