Protein profile

KP13_04630

FeS cluster assembly protein sufD

Genome: KpKP13

Gene: sufD AHE44110.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUU6
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Amino acids 424
Annotations 1
Features 8
PDB binders 0
Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession
KP13_04630
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sufD AHE44110.1
Status
annotated
Amino acids
424
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331
Structure A0A0H3GUU6
Pocket Pocket 3
P2Rank 0.054
Structure A0A0H3GUU6
Pocket Pocket 1
ColabFold model
FPocket 0.219 · Pocket 10
P2Rank 0.089 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 100 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
171 394 Pfam PF01458 SUF system FeS cluster assembly, SufBD
171 394 InterPro IPR000825 SUF system FeS cluster assembly, SufBD
24 419 PANTHER PTHR43575 PROTEIN ABCI7, CHLOROPLASTIC
24 419 InterPro IPR011542 SUF system FeS cluster assembly, SufD
133 410 NCBIfam TIGR01981 Fe-S cluster assembly protein SufD
133 410 InterPro IPR011542 SUF system FeS cluster assembly, SufD
12 421 SUPERFAMILY SSF101960 Stabilizer of iron transporter SufD
12 421 InterPro IPR037284 SUF system FeS cluster assembly, SufBD superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUU6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04630
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.331
6 0.203

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.05 0.006
2 0.95 0.005
3 0.91 0.004
4 0.85 0.003