Protein profile

KP13_04628

Cysteine desulfuration protein sufE

Genome: KpKP13

Gene: sufE AHE44112.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZD1
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Amino acids 138
Annotations 3
Features 8
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
KP13_04628
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sufE AHE44112.1
Status
annotated
Amino acids
138
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0006790 The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.8
DEG E-value
1.71e-35
Localization
Cytoplasmic
ColabFold pLDDT
94.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure A0A0H3GZD1
Pocket Pocket 1
P2Rank
Structure A0A0H3GZD1
Pocket No pockets
ColabFold model
FPocket 0.275 · Pocket 2
P2Rank 0.014 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0006790 The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 138 Gene3D G3DSA:3.90.1010.10 -
1 138 Hamap MF_01832 Cysteine desulfuration protein SufE [sufE].
1 138 InterPro IPR023939 Cysteine desulfuration protein SufE
12 132 Pfam PF02657 Fe-S metabolism associated domain
12 132 InterPro IPR003808 Fe-S metabolism associated domain, SufE-like
5 136 SUPERFAMILY SSF82649 SufE/NifU
6 137 PANTHER PTHR43597 SULFUR ACCEPTOR PROTEIN CSDE
6 137 InterPro IPR003808 Fe-S metabolism associated domain, SufE-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZD1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04628
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.294