Protein profile

KP13_05770

Major outer membrane lipoprotein

Genome: KpKP13

Gene: lpp AHE44114.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU43
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Amino acids 78
Annotations 6
Features 23
PDB binders 1
Druggability 0.521

Overview

Basic information about this protein and its source genome.

Accession
KP13_05770
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lpp AHE44114.1
Status
annotated
Amino acids
78
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008289 Binding to a lipid. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030258 The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. GO:0043580 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
80.6

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.521
Structure A0A0H3GU43
Pocket Pocket 1
P2Rank
Structure A0A0H3GU43
Pocket No pockets
ColabFold model
FPocket 0.631 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0008289 Binding to a lipid.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0030258 The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.
  • GO:0043580 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
4 77 NCBIfam NF040598 Lpp/OprI family alanine-zipper lipoprotein
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
26 78 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 78 Pfam PF04728 Lipoprotein leucine-zipper
26 78 InterPro IPR006817 Lipoprotein leucine-zipper
24 73 SUPERFAMILY SSF58042 Outer membrane lipoprotein
57 78 MobiDBLite mobidb-lite consensus disorder prediction
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 77 FunFam G3DSA:1.20.5.190:FF:000002 Major outer membrane lipoprotein
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 77 Gene3D G3DSA:1.20.5.190 -
1 78 PIRSF PIRSF002855 Murein-lipo
1 78 InterPro IPR016367 Major outer membrane lipoprotein Lpp
3 78 Hamap MF_00843 Major outer membrane lipoprotein Lpp [lpp].
3 78 InterPro IPR016367 Major outer membrane lipoprotein Lpp
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 78 Coils Coil Coil
56 78 MobiDBLite mobidb-lite consensus disorder prediction
1 78 PANTHER PTHR38763 MAJOR OUTER MEMBRANE PROLIPOPROTEIN LPP
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU43
AlphaFold — — full sequence — Viewing
ColabFold KP13_05770
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.521

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
12P
1T8Z
P69776 546.7 Da LogP -0.85 TPSA 142.0 2 viol. ✓ Clean C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.