Protein profile

KP13_04620

putative 4-hydroxyphenylpyruvate dioxygenase

Genome: KpKP13

Gene: AHE44120.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUT7
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Amino acids 617
Annotations 5
Features 21
PDB binders 1
Druggability 0.6

Overview

Basic information about this protein and its source genome.

Accession
KP13_04620
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44120.1
Status
annotated
Amino acids
617
Structure source
AlphaFold + ColabFold
EC
4.2.1.118
GO
GO:0046279 The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0046565 Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.389
Human E-value
2.08e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.6
Structure A0A0H3GUT7
Pocket Pocket 2
P2Rank 0.907
Structure A0A0H3GUT7
Pocket Pocket 1
ColabFold model
FPocket 0.583 · Pocket 1
P2Rank 0.922 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 26 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0046279 The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate.
  • GO:0046565 Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate.
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 617 Hamap MF_02238 3-dehydroshikimate dehydratase.
1 617 InterPro IPR043700 3-dehydroshikimate dehydratase
284 429 Gene3D G3DSA:3.10.180.10 -
284 429 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
430 617 Gene3D G3DSA:3.10.180.10 -
430 617 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
2 271 SUPERFAMILY SSF51658 Xylose isomerase-like
2 271 InterPro IPR036237 Xylose isomerase-like superfamily
432 581 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
432 581 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain
18 261 Pfam PF01261 Xylose isomerase-like TIM barrel
18 261 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
290 409 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
290 409 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain
2 264 PANTHER PTHR12110 HYDROXYPYRUVATE ISOMERASE
289 418 Pfam PF14696 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
2 268 Gene3D G3DSA:3.20.20.150 -
280 613 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
280 613 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
433 572 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
433 572 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUT7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04620
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.6

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.24 0.887
2 8.89 0.476
3 8.29 0.442
4 5.44 0.259
5 1.79 0.034

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
EMC
1CJX
P80064 229.7 Da LogP 0.97 TPSA 0.0 ✓ Ro5 ✓ Clean CC[Hg+]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.