Protein profile

KP13_04599

Putative aliphatic sulfonates-binding protein

Genome: KpKP13

Gene: AHE44141.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZA9
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Amino acids 320
Annotations 3
Features 19
PDB binders 0
Druggability 0.531

Overview

Basic information about this protein and its source genome.

Accession
KP13_04599
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44141.1
Status
annotated
Amino acids
320
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626 Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.531
Structure A0A0H3GZA9
Pocket Pocket 3
P2Rank 0.887
Structure A0A0H3GZA9
Pocket Pocket 1
ColabFold model
FPocket 0.354 · Pocket 2
P2Rank 0.853 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0042626 Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
29 254 SMART SM00062 AABind_6
29 254 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
68 187 Pfam PF09084 NMT1/THI5 like
68 187 InterPro IPR015168 SsuA/THI5-like
25 320 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
106 205 FunFam G3DSA:3.40.190.10:FF:000050 Sulfonate ABC transporter substrate-binding protein
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 24 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
9 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 243 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
32 303 Gene3D G3DSA:3.40.190.10 -
31 311 NCBIfam TIGR01728 aliphatic sulfonate ABC transporter substrate-binding protein
31 311 InterPro IPR010067 Aliphatic sulfonates-binding protein
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
9 312 PANTHER PTHR30024 ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
106 205 Gene3D G3DSA:3.40.190.10 -
29 291 CDD cd13558 PBP2_SsuA_like_2
1 24 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZA9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04599
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.007
17 0.005
9 0.001
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.16 0.887
2 1.72 0.025