Protein profile

KP13_05333

Putative iron compound ABC transport system periplasmic binding component

Genome: KpKP13

Gene: AHE44150.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUR6
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Amino acids 317
Annotations 2
Features 15
PDB binders 3
Druggability 0.109

Overview

Basic information about this protein and its source genome.

Accession
KP13_05333
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44150.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.109
Structure A0A0H3GUR6
Pocket Pocket 3
P2Rank 0.82
Structure A0A0H3GUR6
Pocket Pocket 1
ColabFold model
FPocket 0.481 · Pocket 1
P2Rank 0.769 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 35 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
4 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
13 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 258 PANTHER PTHR30532 IRON III DICITRATE-BINDING PERIPLASMIC PROTEIN
1 17 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
136 316 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
17 297 SUPERFAMILY SSF53807 Helical backbone metal receptor
42 311 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
42 311 InterPro IPR002491 ABC transporter periplasmic binding domain
21 135 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
97 261 Pfam PF01497 Periplasmic binding protein
97 261 InterPro IPR002491 ABC transporter periplasmic binding domain
1 17 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
18 317 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUR6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05333
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.95 0.48

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
EB4
3TLK
P0AEL6 669.6 Da LogP -0.74 TPSA 287.6 3 viol. Alert c1cc(c(c(c1)O)O)C(=O)N[C@H]2COC(=O)[C@H](COC(=O…
ECA
2XV1
P40409 573.6 Da LogP 2.71 TPSA 208.7 2 viol. Alert c1cc(c(c(c1)O)O)C(=O)NCc2cc(cc(c2)CNC(=O)c3cccc…
VBN
3R5T
Q9RCF6 705.7 Da LogP 1.84 TPSA 243.1 3 viol. Alert C[C@@H]1[C@H](N=C(O1)c2cccc(c2O)O)C(=O)NCCCN(CC…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.