Protein profile

KP13_05317

ABC transporter, periplasmic binding protein

Genome: KpKP13

Gene: AHE44165.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPD1
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Amino acids 362
Annotations 0
Features 14
PDB binders 0
Druggability 0.142

Overview

Basic information about this protein and its source genome.

Accession
KP13_05317
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44165.1
Status
annotated
Amino acids
362
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.142
Structure A0A0H3GPD1
Pocket Pocket 7
P2Rank 0.376
Structure A0A0H3GPD1
Pocket Pocket 1
ColabFold model
FPocket 0.578 · Pocket 14
P2Rank 0.379 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 40 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
45 344 Gene3D G3DSA:3.40.190.10 -
59 315 Pfam PF13416 Bacterial extracellular solute-binding protein
59 315 InterPro IPR006059 Bacterial extracellular solute-binding protein
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 362 PANTHER PTHR30006 THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED
142 359 Gene3D G3DSA:3.40.190.10 -
23 362 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
41 341 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPD1
AlphaFold — — full sequence — Viewing
ColabFold KP13_05317
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.46 0.125
2 2.35 0.061
3 1.69 0.029
4 1.16 0.009
5 0.82 0.003