Protein profile

KP13_05316

ABC transporter, permease protein

Genome: KpKP13

Gene: AHE44166.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ88
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Amino acids 589
Annotations 3
Features 64
PDB binders 0
Druggability 0.978

Overview

Basic information about this protein and its source genome.

Accession
KP13_05316
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44166.1
Status
annotated
Amino acids
589
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.978
Structure A0A0H3GZ88
Pocket Pocket 1
P2Rank 0.974
Structure A0A0H3GZ88
Pocket Pocket 1
ColabFold model
FPocket 0.898 · Pocket 43
P2Rank 0.968 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 40 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

64 records
Show feature table
Start End DB Term Name
303 325 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 103 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
146 168 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
512 528 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
428 454 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
511 528 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
387 405 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
364 386 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 13 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
361 577 CDD cd06261 TM_PBP2
361 577 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
329 348 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
70 263 CDD cd06261 TM_PBP2
70 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
125 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
361 580 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
361 580 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
38 69 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
66 273 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
66 273 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
349 359 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
169 205 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
406 427 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 282 Gene3D G3DSA:1.10.3720.10 -
14 282 InterPro IPR035906 MetI-like superfamily
303 585 Gene3D G3DSA:1.10.3720.10 -
303 585 InterPro IPR035906 MetI-like superfamily
273 302 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
535 555 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
324 328 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
70 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 586 SUPERFAMILY SSF161098 MetI-like
300 586 InterPro IPR035906 MetI-like superfamily
5 279 SUPERFAMILY SSF161098 MetI-like
5 279 InterPro IPR035906 MetI-like superfamily
15 588 PANTHER PTHR43357 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
561 585 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
381 577 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
381 577 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
80 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
80 275 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
360 386 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
250 272 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
535 557 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
205 227 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
475 511 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
455 474 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
206 227 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
252 272 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
330 352 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
228 251 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 37 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
104 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
460 479 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
303 323 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
529 534 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
70 92 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
586 589 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
556 560 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
401 423 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
561 583 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ88
AlphaFold — — full sequence — Viewing
ColabFold KP13_05316
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.978
48 0.804
50 0.493

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 38.41 0.96
2 8.61 0.46
3 6.79 0.347
4 5.93 0.291
5 4.8 0.213