Protein profile

KP13_05311

Gluconate 2-dehydrogenase cytochrome c subunit

Genome: KpKP13

Gene: AHE44171.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ84
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Amino acids 446
Annotations 6
Features 37
PDB binders 0
Druggability 0.97

Overview

Basic information about this protein and its source genome.

Accession
KP13_05311
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44171.1
Status
annotated
Amino acids
446
Structure source
AlphaFold + ColabFold
GO
GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0005506 Binding to an iron (Fe) ion. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.97
Structure A0A0H3GZ84
Pocket Pocket 23
P2Rank 0.998
Structure A0A0H3GZ84
Pocket Pocket 1
ColabFold model
FPocket 0.995 · Pocket 28
P2Rank 0.998 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

37 records
Show feature table
Start End DB Term Name
21 156 SUPERFAMILY SSF46626 Cytochrome c
21 156 InterPro IPR036909 Cytochrome c-like domain superfamily
155 302 Gene3D G3DSA:1.10.760.10 -
155 302 InterPro IPR036909 Cytochrome c-like domain superfamily
1 136 Gene3D G3DSA:1.10.760.10 -
1 136 InterPro IPR036909 Cytochrome c-like domain superfamily
29 133 ProSiteProfiles PS51007 Cytochrome c family profile.
29 133 InterPro IPR009056 Cytochrome c-like domain
1 17 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
316 406 ProSiteProfiles PS51007 Cytochrome c family profile.
316 406 InterPro IPR009056 Cytochrome c-like domain
177 293 ProSiteProfiles PS51007 Cytochrome c family profile.
177 293 InterPro IPR009056 Cytochrome c-like domain
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
303 432 Gene3D G3DSA:1.10.760.10 -
303 432 InterPro IPR036909 Cytochrome c-like domain superfamily
22 446 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
327 338 PRINTS PR00605 Class IC cytochrome C signature
327 338 InterPro IPR008168 Cytochrome c, class IC
380 402 PRINTS PR00605 Class IC cytochrome C signature
380 402 InterPro IPR008168 Cytochrome c, class IC
1 439 PIRSF PIRSF000018 Mb_ADH_cytochrome_c
1 439 InterPro IPR014353 Membrane-bound alcohol dehydrogenase, cytochrome c subunit
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
320 426 SUPERFAMILY SSF46626 Cytochrome c
320 426 InterPro IPR036909 Cytochrome c-like domain superfamily
7 425 PANTHER PTHR35008 BLL4482 PROTEIN-RELATED
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
318 402 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
318 402 InterPro IPR009056 Cytochrome c-like domain
31 128 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
31 128 InterPro IPR009056 Cytochrome c-like domain
180 298 SUPERFAMILY SSF46626 Cytochrome c
180 298 InterPro IPR036909 Cytochrome c-like domain superfamily
18 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ84
AlphaFold — — full sequence — Viewing
ColabFold KP13_05311
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.97
12 0.934
9 0.844
27 0.294

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 102.9 0.996
2 26.06 0.91
3 2.96 0.096
4 2.87 0.091
5 1.91 0.039