Protein profile

KP13_05308

Heme exporter protein C

Genome: KpKP13

Gene: ccmC AHE44174.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUP4
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Amino acids 245
Annotations 6
Features 37
PDB binders 0
Druggability 0.877

Overview

Basic information about this protein and its source genome.

Accession
KP13_05308
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ccmC AHE44174.1
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
GO
GO:0015232 Enables the transfer of heme from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
49.398
DEG E-value
1.03e-78
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.877
Structure A0A0H3GUP4
Pocket Pocket 21
P2Rank 0.926
Structure A0A0H3GUP4
Pocket Pocket 1
ColabFold model
FPocket 0.768 · Pocket 8
P2Rank 0.951 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0015232 Enables the transfer of heme from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

37 records
Show feature table
Start End DB Term Name
158 180 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 90 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
222 245 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
200 221 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
201 225 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
201 225 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
45 62 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
45 62 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
62 82 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
62 82 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
100 120 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
100 120 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
121 141 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
121 141 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
156 182 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature
156 182 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
133 149 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
91 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 212 PANTHER PTHR30071 HEME EXPORTER PROTEIN C
27 212 InterPro IPR045062 Cytochrome c-type biogenesis protein CcsA/CcmC
181 199 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
124 146 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
161 180 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 184 Pfam PF01578 Cytochrome C assembly protein
29 184 InterPro IPR002541 Cytochrome c assembly protein
150 160 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
45 225 NCBIfam TIGR01191 heme ABC transporter permease CcmC
45 225 InterPro IPR003557 Cytochrome c-type biogenesis protein CcmC
21 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
114 132 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUP4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05308
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.877
22 0.669
18 0.412
3 0.208

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.98 0.876
2 7.07 0.366
3 4.36 0.182
4 2.17 0.052
5 0.66 0.001