Protein profile

KP13_05306

Cytochrome c-type biogenesis protein ccmE

Genome: KpKP13

Gene: AHE44176.1 ccmE Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ80
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Amino acids 152
Annotations 5
Features 16
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
KP13_05306
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44176.1 ccmE
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0017003 The covalent linkage of heme and a protein. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.329
DEG E-value
1.15e-72
Localization
Unknown
ColabFold pLDDT
85.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure A0A0H3GZ80
Pocket Pocket 2
P2Rank
Structure A0A0H3GZ80
Pocket No pockets
ColabFold model
FPocket 0.487 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 114 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0017003 The covalent linkage of heme and a protein.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 152 MobiDBLite mobidb-lite consensus disorder prediction
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
9 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
30 143 Gene3D G3DSA:2.40.50.140 -
30 143 InterPro IPR012340 Nucleic acid-binding, OB-fold
3 148 PANTHER PTHR34128 CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCME HOMOLOG, MITOCHONDRIAL
3 148 InterPro IPR004329 CcmE/CycJ protein
2 147 Hamap MF_01959 Cytochrome c-type biogenesis protein CcmE [ccmE].
2 147 InterPro IPR004329 CcmE/CycJ protein
31 152 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 137 Pfam PF03100 CcmE
5 137 InterPro IPR004329 CcmE/CycJ protein
30 143 FunFam G3DSA:2.40.50.140:FF:000104 Cytochrome c-type biogenesis protein CcmE
30 143 SUPERFAMILY SSF82093 Heme chaperone CcmE
30 143 InterPro IPR036127 CcmE-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ80
AlphaFold — — full sequence — Viewing
ColabFold KP13_05306
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.241